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Health Library and Resource

NSAIDs up risk of miscarriage by 80%

Pregnant women who take non-steroidal anti-inflammatory drugs (NSAIDs) are significantly increasing their risk of miscarriage, according to a just-published study in the British Medical Journal. 

The study assessed use of NSAIDs, aspirin and paracetamol (acetaminophen) among 1,055 women in their early weeks of pregnancy. 

Results revealed that women who took NSAIDs were 80% more likely to suffer a miscarriage, compared with mothers who avoid these drugs. Risk was significantly higher among women who took NSAIDs close to conception, or took them for more than one week. Prenatal aspirin use was similarly associated with an increased risk of miscarriage. Paracetamol did not appear to influence risk of miscarriage.

BMJ - August 16, 2003;327:368.